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Contact insecticides are an essential component in the fight against vector-borne infectious diseases, such as malaria. When mosquitos contact small crystalline particles of an insecticide they absorb the active substance through their feet to lethal effect at the target site. The NYU investigators recently discovered that insecticides readily form crystal polymorphs with efficacies that are inversely correlated with their thermodynamic stability. That is, polymorphs with higher free energy have greater insecticidal activity. Effective insecticides used in the field, however, require kinetic stability against transformation into their thermodynamically more stable but less active forms. This project aims to develop an integrated experimental-computational framework for the accelerated discovery of crystalline forms that meet these criteria.